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Secondly, the SARS-CoV-2 structural protein inhibits the NRF2 antioxidant response pathway, which normally protects against oxidative damage 12

Neurons of the CNS are very active in oxidative metabolism, as they are constantly exposed to lowtomoderate levels of ROS, and these species are removed by antioxidants (melatonin, vitamin D, vitamin E, glutathione) and antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, etc.)

Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization

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[DOI] [PubMed] [Google Scholar] 143.DiMauro S., Quinzii C.M., Hirano M

Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice