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Animals from the AMPT group received two intra-peritoneal injections of AMPT (25 mg/kg each), separated by 2 hours

However, when the limit for storage of TAGs is reached or adipocyte lipolysis is dysregulated, FAs can accumulate in ectopic tissues such as skeletal muscle and the liver leading to insulin insensitivity and T2D (11)

By providing exogenous pyridoxine that is readily converted to PLP, the injection corrects the coenzyme deficiency and reactivates these metabolic pathways

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Vitamin B12 plays a vital role in the synthesis of essential mood-regulating neurotransmitters, including serotonin and dopamine