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Centaurea cyanus extracted 13-O-acetylsolstitialin A decrease Bax/Bcl-2 ratio and expression of cyclin D1/Cdk-4 to induce apoptosis and cell cycle arrest in MCF-7 and MDA-MB-231 breast cancer cell lines

Perhaps more importantly for tolerability, GIP activation seems to buffer against the nausea commonly caused by GLP-1 stimulation alone

Lower starting lean mass leaves less reserve during rapid loss, which makes strength and protein intake more important outcomes than scale change alone

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Debroy MA, Wolf SE, Zhang XJ, Chinkes DL, Ferrando AA, Wolfe RR, Herndon DN
