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Topically acting drugs offer advantages in these indications since they have a rapid onset

doi: 10.1038/35025070

High interpatient variability of treosulfan exposure is associated with early toxicity in paediatric HSCT: a prospective multicentre study

Pooled data from two independent experiments ( b , d , h )
Oxidative stress and neutrophil activationthe two keystones of ischemia/reperfusion injury