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This was evidenced by the PFS rate (5.6 months vs

These effects appear to be primarily associated with the modulation of signaling pathways such as MAPK, NF-B, and STAT

[30] Low serum thiol levels (precursors to glutathione) have been shown in HIV-infected, injecting drug users (IDU) to be associated with an increased risk of mortality: IDU with low serum thiol levels are 5.65 times more likely to experience an accelerated time-to-death

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(3) Targeted Delivery and Site-Specific Activation: Ensuring brain delivery while controlling peripheral exposure, favoring targeted delivery systems and site/environment-activated prodrugs (e.g., ROS-responsive or target enzyme-activated) to confine activity to the pathological microenvironment, thus balancing brain access and safety [127, 129, 135, 136]