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2D), in contrast to the samples from the I/R group which show mild disorganisation of hepatic cords, followed by mild interstitial oedema, focal erythrocytic extravasation into cystic sinusoidal spaces (yellow arrow), hepatocytes enlargement with focal cytoplasmatic vacuolisation localised around micro-bleedings (black arrow), pyknotic nuclei and chromatin condensation as a sign of necrosis, and diffusely presented binuclear hepatocytes (red arrow) (Fig

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PGC-1 interacts with transcription factors such as PPARs, NRFs, and FOXO1 to integrate signals from oxidative metabolism, gluconeogenesis, and lipid oxidation, serving as a central hub for mitochondrial homeostasis and energy balance

Protective effect of periconceptional folic acid supplements on the risk of congenital heart defects: a registry-based case-control study in the northern Netherlands

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