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Interestingly, repeated OS can initiate and maintain elevated levels of IL-1, leading to a positive feedback loop between OS and neuroinflammatory [104]

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However, the causal relationship between ferroptosis and survival is not yet proven herein

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Thus, targeting the miRNAepigenetic interplay network and histone-modifying enzymes may offer novel therapeutic strategies to suppress malignant transformation in liver fibrosis and modulate the immune microenvironment