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To date, three patterns of p-i-related hypersensitivity reactions have been proposed: the altered peptide model of p-i HLA, the allo-immune model of p-i HLA, and the p-i TCR model ( The altered peptide model of p-i HLA and the allo-immune model of p-i HLA were both developed because some ADRs generated by small molecule drugs are limited exclusively to the HLA allele (36)

Phosphoglycerate Mutase The remaining reactions of glycolysis are aimed at converting the relatively low energy phosphoacyl-ester of 3PG to a high-energy form and harvesting the phosphate as ATP

RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death

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