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This neural pathway regulates melatonin synthesis through norepinephrine release acting on pinealocytes568

Patients treated with taxanes experience symptomatic sensory neuropathy distally at fingertips in hands and feet

In a controlled study, variation in ischemia/reperfusion tolerance across time of day has been previously explored, showing an increase in infarct volume and fibrosis at the onset of activity (ZT12) compared to the beginning of the inactive period (ZT0) in WT mice (Weil et al., 2009)

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