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PubMed, Froese, D

Since then, several clinical studies have shown its safe and effective use - but the pharmacuetical companies have decided not to (yet) pursue FDA-Approval (likely because each new FDA-Approval costs several million dollars to go through the process, and because there are a good deal of drugs used off-label in the way tranexamic acid is for melasma, especially when the drug has a long history of safety and efficacy, as is in this case)

For example, too much vitamin B6 may cause severe skin lesions, along with other symptoms like numbness, digestive issues, and poor muscle control, according to Mayo Clinic

Weed Research 59 , 324-338

The secondary phase is a combination of physiological responses to the primary insult, such as excitotoxicity and an ongoing inflammatory process that includes immune system access to the mechanically injured tissue (76, 77)

They simply describe what people commonly report online and in some clinics