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Knockdown of ARNTL2 significantly decreases the expression levels of Nrf2, SLC7A11, and CDGSH iron-sulfur domain protein 1 of lung adenocarcinoma cells, and increases the sensitivity to ferroptosis

The Liver

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Arsenic tolerances in rice ( Oryza sativa ) have a predominant role in transcriptional regulation of a set of genes including sulphur assimilation pathway and antioxidant system

In addition to an inflammatory reaction, the pathogenesis of OA also includes the degeneration of articular cartilage, and chondrocytes, as the only articular chondrocytes, play an important role in this process

Additionally, the oxidative degradation of PUFAs generates two secondary lipid peroxides, 4-hydroxy-2-nonenal (4-HNE) and malondialdehyde (MDA), which are highly expressed during the onset of ferroptosis and serve as markers of this process