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1C), the methyltransferase that was also significantly elevated in SSc skin biopsies 24

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Systems modelling predicts chronic inflammation and genomic instability prevent effective mitochondrial regulation during biological ageing

In contrast, DIO mice in both groups switched from WD to LD each had significantly increased Proteobacteria relative abundance (represented solely by the genus Parasutterella ) compared to both the WD and the LD controls, suggesting that Proteobacteria relative abundance may be largely influenced by stress or the differences in net energy expenditure (or associated body weight changes) caused by the diet switch

Erysipelatoclostridium relative abundance was significantly greater in the vehicle-treated group switched from WD to LD relative to all other groups (before FDR correction, Fig