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The effects of a series of w-phosphonic a-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations

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The postulated mechanism of action here is that APAP induces generation of ROS and decreases GSH levels, sensitizing cells to the toxic effect of staurosporine (131)

Biochim Biophys Acta 1864(2):520532

Cerebrospinal fluid concentrations rise within approximately 30 minutes of an intranasal dose and are reported to reach roughly 60 to 70 percent of corresponding plasma concentrations in rodent studies, a striking ratio for a peptide of this size