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Endogenous glutamate generated from glutamine via PAG may enter the TCA cycle via AAT (left side of neuron) while exogenous glutamate taken up from the extracellular space may be incorporated into the TCA cycle via GDH (right side of the neuron) FTD3 astrocytic glutamate uptake is upregulated whilst glutamate metabolism is largely maintained

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Author contributions XZ, YM, JM, LY and QS performed the experiments

Estrogen suppresses transcription of lipoprotein lipase gene

Mitochondrial protein acetylation is driven by acetyl-CoA from fatty acid oxidation
