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Fan, Z., Huang, J., Huang, H

The same phthalate metabolite can also activate PPAR, which, in addition to regulating adipocyte differentiation and metabolism of lipids and glucose [148,149], when overexpressed, has been associated with more aggressive features in TC, i.e., increased cell growth and tendency to generate metastasis, and appears to promote the transition from differentiated to TC undifferentiated histological types with a consequent worse prognosis [150]

Oncogenesis 6:e371 Farkhondeh T, Pourbagher-Shahri AM, Azimi-Nezhad M, Forouzanfar F, Brockmueller A, Ashrafizadeh M, Talebi M, Shakibaei M, Samarghandian S (2021) Roles of nrf2 in gastric cancer: targeting for therapeutic strategies

IGFBP-6: At the crossroads of immunity, tissue repair and fibrosis

Interestingly, they found aberrations in ROS clearance pathways, including elevated glutathione levels, decreases in mitochondrial superoxide dismutase levels, and glutathione peroxidase 4 mediated lipid oxidative damage

These limitations hinder direct application to patients and highlight the need for larger translational and clinical research to confirm the key miRNASIRT1 circuits
