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Widdowson et al., 1996)
"BPC 157 and blood vessels." Current Pharmaceutical Design
Instead of being filtered and excreted by kidney, those uremic toxins accumulate in blood and lead to a deficient erythropoietin (EPO) production by the kidney interstitial fibroblasts (peritubular cells of kidneys), resulting in a defective erythropoiesis due to a decrease in erythrocyte production [9,10]
10.1016/j.jmu.2015.02.001 J
Nitric oxide modulation appears to affect blood flow and vascular tone, while VEGF-related pathways support new vessel formation and tissue recovery
The same observations were found in rat brains in vivo (Morello et al., 2007) and in dopamine neurons (Neely et al., 2017) and SH-SY5Y cells in vitro (Maddirala et al., 2015)
