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Nicotinamide N-methyltransferase (NNMT) is an enzyme that plays a crucial role in cellular metabolism and energy homeostasis
In addition, fibronectin extra domain A (EDA) fragments, which are increased in patients with scleroderma, stimulate collagen production via Toll-like receptor 4 (TLR4) signalling and induce myofibroblast differentiation and ECM stiffness
Lev N, Ickowicz D, Barhum Y, Lev S, Melamed E, Offen D
