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Interestingly, this area gets its name from its dark color, caused by high levels of neuromelanin, which is also a downstream metabolite of L-DOPA (Carballo-Carbajal et al
Researchers must carefully consider these pharmacokinetic challenges

Faltas B

doi: 10.1152/ajpheart.00416.2017 [DOI] [PMC free article] [PubMed] [Google Scholar] 246.Colman R, Tchkonia T, Pirtskhalava T, et al

Somatostatin secreted by islet delta-cells fulfills multiple roles as a paracrine regulator of islet function

Annals of the New York Academy of Sciences , 1112, 4251
