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In summary, this study increases our understanding of the role of GPx1 in the induction of protective autophagy in PDA cells under extreme glucose starvation and may provide new therapeutic targets or innovative therapies.

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It is primarily stored in the mitochondria the energy-producing structures within cells where it plays a vital role in converting methylmalonyl-CoA to succinyl-CoA, a key step in the citric acid cycle that supports energy production