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Minchinton et al., 1995

Antioxidant and pro-oxidant activities of melatonin in the presence of copper and polyphenols in vitro and in vivo

To avoid these undesired cellular destructions, organisms have evolved the glutathione-dependent glyoxalase pathway 3 and NAD(P)H-dependent Aldo-Keto reductase pathway 11

[DOI] [PMC free article] [PubMed] [Google Scholar] 71.Shih A.Y., Erb H., Sun X., Toda S., Kalivas P.W., Murphy T.H

Influencing cell signaling pathways, but not direct chemical effects of melatonin has also been proposed as the prooxidant mechanism of the substance

Therapeutic Adv Gastroenterol 16:17562848231191664 Park NW, Lee ES, Ha KB, Jo SH, Kim HM, Kwon M-H, Chung CH (2023b) Umbelliferone ameliorates hepatic steatosis and lipid-Induced ER stress in High-Fat Diet-Induced obese mice