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Taken together, while direct clinical evidence in women with LPD is lacking, converging findings from menstrual cycle observations, animal models, and interventional studies suggest that progesteronekisspeptin signaling may contribute to GnRH/LH dysregulation and impaired follicular development, warranting further investigation (Fig

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Serum samples were analyzed for liver function markers (Alanine transferase/ALT, Aspartate transferase/AST), renal function markers (Urea nitrogen, Creatinine/Cr), and myocardial enzyme indexes (Creatine Kinase/CK, Creatine Kinase-MB/CK-MB, Lactate Dehydrogenase-L/LDH-L)

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