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This enhancement led to greater protein stability and elevated METTL3 expression, which in turn upregulated the m6A level and mRNA expression of the transferrin receptor, further inducing ferroptosis in the PC12 cells [112]

Since they also generate ROS as a byproduct in this energy production process, we need to protect them from ROS attacks to regulate their function

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Considerable progress has been made in developing pharmacological agonists and antagonists for the treatment of these ferroptosis-related conditions

[DOI] [PubMed] [Google Scholar] 37.Futakuchi A., Morimoto T., Ikeda Y., Tanihara H., Inoue T., ROCK-S study group collaborators 2020 Intraocular pressure-lowering effects of ripasudil in uveitic glaucoma, exfoliation glaucoma, and steroid-induced glaucoma patients: ROCK-S, a multicentre historical cohort study

The re-examination showed that the volume of tumor lesion was shrunk by more than 30% according to the evaluation criteria for solid tumors (RECIST 1.1)