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The improved genomic characterization of cutaneous melanoma represents a critical asset with diagnostic and prognostic implications, helping the dermatopathologists in the challenging classification of melanocytic lesions as benign, intermediate, or malignant ( As a matter of fact, in the era of targeted therapies, molecular subtyping of melanoma is replacing the traditional clinicopathological classification

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18 to determine weighted genome-wide significance thresholds for different variant classes based on the total number of variants tested per class: loss-of-function ( N =6,476