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In contrast to GSH synthesis, which occurs intracellularly, GSH degradation occurs exclusively in the extracellular space, and in particular, on the surface of cells that express the ectoenzyme -glutamyl transpeptidase (also called -glutamyl transferase or GGT) (Figure 1C)

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The most important cause of postsinusoidal hypertension is hepatic vein occlusion or Budd-Chiari syndrome, 149A in which sudden obstruction or occlusion of the hepatic veins (associated with myeloproliferative disorders in half of cases) causes hepatomegaly, abdominal pain, severe ascites, mild jaundice, and eventually portal hypertension and liver failure