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The brain is extremely sensitive to any reduction in oxygen supply and neurons begin to die within minutes of oxygen restriction

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Although severe and life-threatening anaemia due to PA is rare today, PA remains a specific condition that requires recognition and appropriate management

Several mechanisms have been proposed to explain chronic hyperglycemia-induced nerve damage, such as intracellular accumulation of sorbitol, glycation reactions, and oxidative and nitrosative stress (reviewed in 69)

88.8% of patients tolerated treatment successfully