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For example, chrysin from acacia honey promoted mitochondrial apoptosis in hepatocellular carcinoma via downregulation of Bcl-2 and upregulation of Bax

Author contributions Conceived and designed the experiments: Bernard Schmitt, Morgane Vicenzi and Frederic M

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doi: 10.21608/avmj.2013.191997 160

HpGroEL and HpTpx are covalently bound and inhibited by Metro and Metro-P3 after reductive activation As binding of Metro and derivatives to HpGroEL and HpTpx requires the in situ activation of the nitro group under microaerophilic or anaerobic conditions, direct inhibition and binding assays with purified enzymes in vitro were challenging (Supplementary Figs