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Salas JA Engineering Deoxysugar Biosynthetic Pathways from Antibiotic-Producing Microorganisms

However, a small fraction converts into a toxic metabolite called NAPQI (N-acetyl-p-benzoquinone imine)

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For example, the activation of inflammasomes, especially the NLRP3 inflammasome, leads to endothelial dysfunction, plaque formation, and myocardial injury by inducing the release of pro-inflammatory cytokines such as IL-1, IL-18, and IL-6 ( 5.1 The anti-inflammatory effect in atherosclerosis Silybin has been shown to reduce the inflammatory response in atherosclerotic lesions, with its core mechanism involving the direct inhibition of key pro-inflammatory signaling pathways

2016;311:G1009G1017

[DOI] [PubMed] [Google Scholar] 156.Magalhes P.V., Dean O.M., Bush A.I., Copolov D.L., Malhi G.S., Kohlmann K., Jeavons S., Schapkaitz I., Anderson-Hunt M., Berk M
