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Resistance to mTORC1 inhibitors, such as temsirolimus involves an upregulation of glutamine metabolism, PTEN expression, alteration of the p53 response to nucleolar stress, a negative feedback activation of the PI3K/AKT signaling, increased rates of clonal and non-clonal chromosome aberrations, and changes in the copy number alterations pattern [412,413,414]

The largest case series in the literature reports 58 patients with bone marrow necrosis with fat embolism syndrome

Inflammation can be inhibited by negative regulators of ferroptosis

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Allicin may enhance the effects of other antibiotics, aiding in the fight against antibiotic resistance

Under normoxic conditions, the proline residue of HIF1 is hydroxylated