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The tissue becomes sensitized, developing localized immune memory that triggers faster and stronger responses with each subsequent injection

TJs are comprised of various proteins traversing the intercellular cleft such as occludins and claudins, which are further linked to important scaffolding proteins as well as other regulatory proteins like cingulin, ZO-1, ZO-2, and ZO-3 [21]

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Porosity and thickness of the vertebral endplate depend on local mechanical loading

The combined treatment group consisted of teeth that received the same injection dose (1 10 7 cells/0.6 mL) in both trials: 33 teeth from the investigator-initiated study and 18 teeth from the Phase I trial