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This idea dates back to seminal work from Eagle, who showed that supplementation with extracellular GSH supports cell growth in cystine-free conditions 22

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Another study hypothesized that MTs might protect the heart from diabetes-linked alterations by impeding nitration of SCOT Trp374, conserving its enzymatic function in mitochondrial energy metabolism [20]

doi: 10.1016/j.fertnstert.2005.03.064

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