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[DOI] [Google Scholar] 74.Duhig K.E., Myers J., Seed P.T., Sparkes J., Lowe J., Hunter R.M., Shennan A.H., Chappell L.C., on behalf of the PARROT Trial Group Placental growth factor testing to assess women with suspected pre-eclampsia: A multicentre, pragmatic, stepped-wedge cluster-randomised controlled trial

An additional insult or pathogenic factor, often referred to in the literature as the second hit, is required to trigger the progression from simple steatosis to steatohepatitis (MASH), characterized by hepatocellular injury, inflammation, and varying degrees of fibrosis [32]