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One detail that shapes the clinical narrative is that plasma DSIP levels show a diurnal pattern , reported as lower in the morning and higher in the evening

Long-term effects of stimulant medications on the brain: possible relevance to the treatment of attention deficit hyperactivity disorder

Oxidative Medicine and Cellular Longevity , 2012, 324832

Although often applied, the immortalized HK-2 cell line lacks the expression of OAT1, OAT3, OCT2, MRP2, and BCRP, and may be not a representative model to study nephrotoxicity (Jenkinson et al

"Systematic review and pragmatic clinical approach to oral and nasal vitamin B12 (cobalamin) treatment in patients with vitamin B12 deficiency related to gastrointestinal disorders"

10.1111/nyas.15187 22 GrantB.KeanJ.ValiN.CampbellJ.MadenL.BijralP.et al (2023b)