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Research has demonstrated a negative correlation between leukocyte concentration in semen and sperm concentration and vitality, indicating that inflammation of the male reproductive system significantly impairs reproductive function [1]

doi: 10.1021/acsomega.8b02161 54

J Oral Biol Craniofac Res

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Furthermore, F 2 -IsoPs have been shown to increase in different biofluids over the human lifespan (Reference Montine, Peskind and Quinn67) and to be higher in elderly versus younger subjects (Reference Sekhar, Patel and Guthikonda21)