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Although localized ccRCC can be effectively treated with surgery, metastatic disease is associated with a poor prognosis

The cytotoxic T cells and newly emerging cytotoxic CD4 + T cells were enriched in patients with GI PACS, indicating its correlation with unique T cell clonal and transcriptome (Su et al., 2022)

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highlight that these emerging technologies lay the groundwork for CRNs to become key components in future personalized cancer therapy approaches [32]