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In diabetic models, elevated GMP levels are linked to metabolic stress and disrupted guanine nucleotide cycling, which can impair axonal transport and neurotrophic signaling (Wang et al., 2011)

Their inclusion in both preclinical and experimental medicine studies offers a valuable translational tool, allowing for direct comparisons across models and human populations

Metal-based superoxide dismutase and catalase mimics reduce oxidative stress biomarkers and extend life span of Saccharomyces cerevisiae

Daily oral zeaxanthin administration from weeks 619 could reduce depressive-like behaviors in the OFT and FST of diabetic rats

[DOI] [PMC free article] [PubMed] [Google Scholar] 108.Ducker GS, Rabinowitz JD

While glutamate is typically abundant in the standard human diet, cysteine and glycine are frequently depleted, especially during times of chronic metabolic stress, severe viral infection, or the natural aging process