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After 3 months advanced glycosylation end-products (AGEs) -formed from non-enzymatic interactions between glucose and amino acid residues and leading to irreversible cross linking of tissue proteins-can be found in the mesothelial and submesothelial layer (Yamada et al., 1994)
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It is needed for normal growth and development
Riddle and Albert, 1997
It suggests a role for hormonal status as a risk factor in the pathogenesis of these lesions
