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Our study also identified berberine and palmatine derived from CDD-2103 which particularly retain in mesenteric lymph node of colitis mice may contribute to the inhibitory effect of CDD-2103 on colitis

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There were 5 patients per cohort in Part B, with the exception of the 0.1 mg/kg ImmTOR + 0.4 mg/kg pegadricase group for which an additional 5 patients were added under a protocol revision to increase the N, as these patients showed a heterogenous effect of ImmTOR on anti-uricase IgG responses and maintenance of low sUA

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