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Lipid diffusion was measured with the GROMACS function gmx msd , which computes the mean square displacement of molecules from their initial position

In the liver, glutathione S-transferase enzymes conjugate GSH to reactive metabolites and toxins, making them water-soluble for excretion a process central to Phase II detoxification

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However, inconsistent effects on clinical symptoms across trials, heterogeneous dosing schedules, and methodological limitations (including small sample sizes and variable baseline vitamin D status) mean that the overall evidence for routine vitamin D use in endometriosis remains suggestive rather than definitive

For studies requiring sustained peptide exposure, twice-daily dosing maintains more consistent plasma levels than single daily administration