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In AD, when the function of the BBB is impaired, neurotoxic proteins such as beta-amyloid peptide (A) and Tau protein cannot be effectively cleared and will accumulate in the cerebral blood vessels and brain parenchyma, accelerating neuronal damage and neurodegeneration (Lee et al., 2022

129 Meanwhile, cotransporters such as NKCC1 regulate the ion balance by transporting Na + , K + , Cl

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The main elements are Methionine (M), Inositol (I), and Choline (C)

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