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This gene (located at 3p21.3) is expressed in basal keratinocytes of the epidermis and encodes type VII collagen
This involves ensuring that the costs associated with drug development, production, and delivery do not make the therapy prohibitively expensive for patients or healthcare providers

Melanotan-1s bioactivity depends on its specific tertiary conformation once the molecule unfolds, it cannot refold into the bioactive shape, and it will not bind to melanocortin-1 receptors regardless of dose or storage

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