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There have been some important randomised controlled trials using OROS-MPH with interesting findings

In the late 1990s, researchers began identifying glaucoma gene mutations, including several in a gene that encodes for the protein TIGR found in the trabecular meshwork

thus, analyses are based on 8 participants in both the 70%EX and IIR-70%EX trials and 7 in the 70/95%EX trial

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Doses larger than 1 g have been associated with an increase in side effects, including nausea and diarrhea

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