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S2CID 18272815

Ferroptotic cell death is also capable of releasing DAMPs that promote sterile inflammation and the development of numerous inflammatory diseases, for example, via its receptor for advanced glycation end-products (RAGE) to activate NF-B [51, 52] (Fig

FASN expression decreases in EC-enriched tissues of diabetic mice, whereas insulin restores its levels and eNOS activity, highlighting the importance of DNL in glucose-sensitive endothelial regulation

Other contributors to the complex environmental milieu include radiation (e.g., UV), restricted nutrient availability, and elevated concentrations of airborne molecules and gases such as ozone, particulate matter from combustion, and carbon dioxide (CO 2 )
