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[2] It is the main and most common cause of vitamin B 12 deficiency anemia in developed countries, [3] and is characterized by a triad of symptoms: [2] Anemia with bone marrow promegaloblastosis (megaloblastic anemia)

Apnea after injury was not observed, and there were no mortalities

Moreover, the latest literature data indicate clearly that although numerous preventive therapies have been tested for their potential utility to alleviate CIPN, it is currently still not preventable [138,139,140], and many strategies that were tested were found to be ineffective

Induction of interleukin-9-producing mucosal mast cells promotes susceptibility to IgE-mediated experimental food allergy

doi: 10.1016/j.cmet.2015.12.006 10 ONeillLAKishtonRJRathmellJ

Replacement of Asn450 by glutamine (N450Q), aspartate (N450D), and alanine (N450A) showed a significant increase in transpeptidase activity up to 3.6-fold enhancement and minor maturational defects, suggesting significant contribution of this residue in substrate binding and catalysis