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It is possible that the majority of dopamine release to the striatum is mediated by serotonergic neurons without regulation, resulting in dyskinesias

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Does adding cagrilintide to tirzepatide provide additional benefit

This reversal was seen also on the background of the disturbed prostaglandins- and NO-systems, prostaglandins synthesis inhibition as well as NO-overstimulation (NOS-substrate L-arginine) or NO-blockade (N(G)-nitro-L-arginine methyl ester (L-NAME)) (Stupnisek et al., 2012