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J Infect Dis 1997;176:1517-23

It seems to promote M2 macrophage polarization as part of its mechanism

In that small subset, melatonin did not cause a detectable increase in severe adverse events (rate ratio = 0.88 [0.52, 1.50]) or withdrawals due to adverse events (0.93 [0.24, 3.56]), but it did appear to increase the risk of adverse events such as drowsiness, headache, and dizziness (1.40 [1.15, 1.69])

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