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Sleep deprivation induces upregulation of the main Cl-accumulating transporter, NKCC1/SLC12A2, resulting in increased neuronal Cl accumulationa reversible process modified by the NKCC1 inhibitor bumetanide 107
Hepatology 52, 20652076 (2010)
Buse JB, Henry RR, Han J, Kim DD, Fineman MS, Baron AD
These approaches provide a promising avenue for enhancing the efficacy of existing treatments while minimizing side effects and improving patient outcomes
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Meanwhile, effects of histone methylation depend on where modification occurs
