epatic reduced glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis Dysregulation of glutathione synthesis in

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Selenium is one of the key components of glutathione peroxidase, an enzyme that catalyzes the reduction of hydrogen peroxide and organic peroxides to water and the corresponding alcohols by reduced glutathione, significantly reducing the production of free radicals (85, 88)

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Concurrently, ammonia inhibits the catalytic function of P4HA1 by chelating iron and competing with 2-oxoglutarate (2OG), thereby accelerating T cell exhaustion (173175)

Cardiovasc Res 2020;116:10711084