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Leitl, M
Progressive vessel narrowing causes exertional ischemia (intermittent claudication) and chronic hypoperfusion signs like dermal atrophy, hair loss, and absent pulses
Sci Transl Med 2010;2:ra67 10.1126/scitranslmed.3001262 [DOI] [PMC free article] [PubMed] [Google Scholar] 32

The result is selective apoptosis of FOXO4-high senescent cells, leaving FOXO4-low non-senescent cells intact a selectivity that makes it a uniquely powerful molecular probe for studying the contribution of senescent cell accumulation to tissue dysfunction, ageing phenotypes, and disease biology

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