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In this context, combining targeted ammonia metabolism intervention (e.g., using the GLS1 inhibitor CB-839) with CAR-T cell infusion not only blocks tumor cell utilization of ammonia but also enhances T cell adaptability through metabolic plasticity, thereby simultaneously alleviating the immunosuppressive microenvironment and prolonging CAR-T cell persistence (156, 159)

However, synthetic materials may lack the specific biological signals and microenvironments present in natural materials that are crucial for cell behavior and tissue regeneration

When you are ready to start a new protocol, remove only the vials you need

Br J Surg 1997;84:13669

Integrated stress response Studies in various models of mitochondrial dysfunction have consistently identified an activation of the integrated stress response (ISR)