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Researchers should consult primary literature (Pickart et al., 2012

Optional information about ones urine albumin-to-creatinine ratio (a marker of kidney function), hemoglobin A1c (HbA1c, a marker of blood glucose control), and zip code (a marker used to estimate social determinants of health) can be added to improve accuracy when these numbers are relevant and available

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The gamma-glutamyl cycle does allow some tissues (particularly the liver, kidney, and lung epithelium) to utilize extracellular glutathione more directly via membrane transporters

Existing cell (cybrid) and animal models are insufficient, particularly due to issues such as tissue specificity and heteroplasmy shift

Lancet Gastroenterol Hepatol 2023;8:17991.ArticlePubMed 82